General Information of the Compound
Compound ID
CP0453800
Compound Name
10,11-dihydro-N,N,beta-trimethyl-5H-dibenz[b,f]azepine-5-propanamine
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Synonyms
(+)-Trimipramine
(-)-Trimipramine
1-(3-Dimethylamino-2-methylpropyl)-4,5-dihydro-2,3:6,7-dibenzazepine
10,11 Dihydro-N,N,beta-trimethyl-5H-dibenz(b,f)azepine-5-propanamine
10,11-Dihydro-5-(3-dimethylamino-2-methylpropyl)-5H-dibenz(b,f)azepine
10,11-dihydro-N,N,beta-trimethyl-5H-dibenz[b,f]azepine-5-propanamine
2'-Metil-3'-dimetilamino-propil-5-iminodibenzile
2'-Metil-3'-dimetilamino-propil-5-iminodibenzile [Italian]
3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-amine
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethylpropan-1-amine
5-(3-(Dimethylamino)-2-methylpropyl)-10,11-dihydro-5H-dibenz(b,f)azepine
5-(gamma-Dimethylamino-beta-methylpropyl)-10,11-dihydro-5H-dibenzo(b,f)azepine
5-(gamma-dimethylamino-beta-methylpropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine
5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenz[b,f]azepine
5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-, (+)-(9CI)
5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-, (-)-(9CI)
7162 RP
Beta-Methylimipramine
FI 6120
IL 6001
IL-6001
RP-7162
Rhotrimine (TN)
Sapilent
Stangyl
Stangyl (TN)
Surmontil
Surmontil (TN)
Surmontyl
Trimeprimina
Trimeprimina [Italian]
Trimeprimine
Trimeproprimin
Trimeproprimine
Trimipramina
Trimipramina [INN-Spanish]
Trimipramine
Trimipramine (USAN/INN)
Trimipramine [USAN:INN:BAN]
Trimipramine, (-)-Isomer
Trimipraminum
Trimipraminum [INN-Latin]
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Structure
Formula
C20H26N2
Molecular Weight
294.442
Canonical SMILES
CC(CN(C)C)CN1c2ccccc2CCc2ccccc12
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InChI
InChI=1S/C20H26N2/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22/h4-11,16H,12-15H2,1-3H3
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InChIKey
ZSCDBOWYZJWBIY-UHFFFAOYSA-N
CAS
739-71-9
3564-75-8
3564-66-7
Physicochemical Property
logP
4.121
Rotatable Bonds
4
Heavy Atom Count
22
Polar Areas
6.48
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 5584
SID: 14751475
ChEMBL ID
CHEMBL644
DrugBank ID
DB00726
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03795, Solute carrier family 22 member 1
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 27700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT02031, Voltage-dependent N-type calcium channel subunit alpha-1B
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000004 SH-SY5Y
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 11000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Trimipramine )
Drug Name Trimipramine
Company Odyssey Pharmaceuticals Inc
Indication
Major depressive disorder
Approved
Target(s)
Norepinephrine transporter (NET)
 Target Info 
Inhibitor