General Information of the Compound
Compound ID
CP0453755
Compound Name
2-(benzylamino)-6-(4-fluoropyridine-3-carbonyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carbonitrile
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Structure
Formula
C21H17FN4OS
Molecular Weight
392.459
Canonical SMILES
Fc1ccncc1C(=O)N1CCc2c(C1)sc(NCc1ccccc1)c2C#N
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InChI
InChI=1S/C21H17FN4OS/c22-18-6-8-24-12-17(18)21(27)26-9-7-15-16(10-23)20(28-19(15)13-26)25-11-14-4-2-1-3-5-14/h1-6,8,12,25H,7,9,11,13H2
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InChIKey
QEHVAUCFDVJQOX-UHFFFAOYSA-N
Physicochemical Property
logP
3.96448
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
69.02
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118735967
ChEMBL ID
CHEMBL3422883
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01994, Metabotropic glutamate receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000447 Chem-3 Mus musculus (Mouse)  1
1
IC50 = 1240 nM
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