General Information of the Compound
Compound ID
CP0451118
Compound Name
(R)-[(4aR,5S)-4a-methyl-1-(4-methylphenyl)-5,6,7,8-tetrahydro-4H-benzo[f]indazol-5-yl]-phenylmethanol
    Show/Hide
Formula
C26H28N2O
Molecular Weight
384.523
Canonical SMILES
Cc1ccc(cc1)-n1ncc2C[C@]3(C)[C@H](CCCC3=Cc12)[C@@H](O)c1ccccc1
    Show/Hide
InChI
InChI=1S/C26H28N2O/c1-18-11-13-22(14-12-18)28-24-15-21-9-6-10-23(25(29)19-7-4-3-5-8-19)26(21,2)16-20(24)17-27-28/h3-5,7-8,11-15,17,23,25,29H,6,9-10,16H2,1-2H3/t23-,25+,26+/m1/s1
    Show/Hide
InChIKey
WZLSYKQRHBXSKA-AFESJLNVSA-N
Physicochemical Property
logP
5.66022
Rotatable Bonds
3
Heavy Atom Count
29
Polar Areas
38.05
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
ChEMBL ID
CHEMBL4860401
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00870, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000230 INS-1 832/13 Rattus norvegicus (Rat)  2
1
EC50 = 10000 nM
   TI
   LI
   LO
   TS
2
IC50 = 398.11 nM
   TI
   LI
   LO
   TS