General Information of the Compound
Compound ID
CP0451104
Compound Name
(R)-[(4aR,5S)-4a-methyl-1-(4-methylphenyl)-5,6,7,8-tetrahydro-4H-benzo[f]indazol-5-yl]-(3,4-difluoro-5-methoxyphenyl)methanol
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Structure
Formula
C27H28F2N2O2
Molecular Weight
450.529
Canonical SMILES
COc1cc(cc(F)c1F)[C@H](O)[C@H]1CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(C)cc1
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InChI
InChI=1S/C27H28F2N2O2/c1-16-7-9-20(10-8-16)31-23-13-19-5-4-6-21(27(19,2)14-18(23)15-30-31)26(32)17-11-22(28)25(29)24(12-17)33-3/h7-13,15,21,26,32H,4-6,14H2,1-3H3/t21-,26+,27+/m1/s1
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InChIKey
IEHMKTVARCQJKJ-AIGMYPEUSA-N
Physicochemical Property
logP
5.94702
Rotatable Bonds
4
Heavy Atom Count
33
Polar Areas
47.28
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 142819626
ChEMBL ID
CHEMBL4871954
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00870, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000230 INS-1 832/13 Rattus norvegicus (Rat)  2
1
EC50 = 100000 nM
   TI
   LI
   LO
   TS
2
IC50 = 158.49 nM
   TI
   LI
   LO
   TS