General Information of the Compound
Compound ID
CP0450384
Compound Name
17alpha-[(4-Hydroxymethylphenyl)]ethynyl-estra-1,3,5-(10)-triene-3,17beta-diol
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Structure
Formula
C27H30O3
Molecular Weight
402.534
Canonical SMILES
C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CC[C@@]2(O)C#Cc1ccc(CO)cc1
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InChI
InChI=1S/C27H30O3/c1-26-13-11-23-22-9-7-21(29)16-20(22)6-8-24(23)25(26)12-15-27(26,30)14-10-18-2-4-19(17-28)5-3-18/h2-5,7,9,16,23-25,28-30H,6,8,11-13,15,17H2,1H3/t23-,24-,25+,26+,27+/m1/s1
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InChIKey
BNTDWNVWYDBRAW-VKINHPFQSA-N
Physicochemical Property
logP
4.5234
Rotatable Bonds
1
Heavy Atom Count
30
Polar Areas
60.69
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
3
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46231169
ChEMBL ID
CHEMBL597693
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00886, Estrogen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000211 Ishikawa Homo sapiens (Human)  1
1
EC50 = 27 nM
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