General Information of the Compound
Compound ID
CP0450340
Compound Name
N-[1-[(3-bromo-4-piperidin-4-yloxyphenyl)methyl]piperidin-4-yl]-6-(4-methylphenyl)-1-benzothiophene-2-carboxamide
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Structure
Formula
C33H36BrN3O2S
Molecular Weight
618.641
Canonical SMILES
Cc1ccc(cc1)-c1ccc2cc(sc2c1)C(=O)NC1CCN(Cc2ccc(OC3CCNCC3)c(Br)c2)CC1
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InChI
InChI=1S/C33H36BrN3O2S/c1-22-2-5-24(6-3-22)25-7-8-26-20-32(40-31(26)19-25)33(38)36-27-12-16-37(17-13-27)21-23-4-9-30(29(34)18-23)39-28-10-14-35-15-11-28/h2-9,18-20,27-28,35H,10-17,21H2,1H3,(H,36,38)
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InChIKey
KMAPUDGGZZOQRR-UHFFFAOYSA-N
Physicochemical Property
logP
7.16442
Rotatable Bonds
7
Heavy Atom Count
40
Polar Areas
53.6
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 123185525
ChEMBL ID
CHEMBL3898238
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02463, Urotensin-2 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 140 nM
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