General Information of the Compound
Compound ID
CP0450242
Compound Name
US8933079, 5.14
    Show/Hide
Structure
Formula
C26H29N3O4
Molecular Weight
447.535
Canonical SMILES
Cc1cc(CN2CCC(C)(O)C2)ccc1C(=O)Cn1ncc(OCc2ccccc2)cc1=O
    Show/Hide
InChI
InChI=1S/C26H29N3O4/c1-19-12-21(15-28-11-10-26(2,32)18-28)8-9-23(19)24(30)16-29-25(31)13-22(14-27-29)33-17-20-6-4-3-5-7-20/h3-9,12-14,32H,10-11,15-18H2,1-2H3
    Show/Hide
InChIKey
RRXVYXVFENQLEQ-UHFFFAOYSA-N
Physicochemical Property
logP
2.97032
Rotatable Bonds
8
Heavy Atom Count
33
Polar Areas
84.66
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 71730531
ChEMBL ID
CHEMBL3686829
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000076 CHO/Galpha16 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS