General Information of the Compound
Compound ID
CP0449923
Compound Name
4-chloro-N-[3-cyano-6-(5-propan-2-yl-1H-pyrazole-3-carbonyl)-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]benzamide
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Structure
Formula
C22H20ClN5O2S
Molecular Weight
453.955
Canonical SMILES
CC(C)c1cc([nH]n1)C(=O)N1CCc2c(C1)sc(NC(=O)c1ccc(Cl)cc1)c2C#N
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InChI
InChI=1S/C22H20ClN5O2S/c1-12(2)17-9-18(27-26-17)22(30)28-8-7-15-16(10-24)21(31-19(15)11-28)25-20(29)13-3-5-14(23)6-4-13/h3-6,9,12H,7-8,11H2,1-2H3,(H,25,29)(H,26,27)
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InChIKey
QWDZZXBTYVQINQ-UHFFFAOYSA-N
Physicochemical Property
logP
4.57048
Rotatable Bonds
4
Heavy Atom Count
31
Polar Areas
101.88
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118735953
ChEMBL ID
CHEMBL3422869
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01994, Metabotropic glutamate receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000447 Chem-3 Mus musculus (Mouse)  1
1
IC50 = 12200 nM
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