General Information of the Compound
Compound ID
CP0449030
Compound Name
3-Amino-N-((R)-1-(2,4-dichloro-benzyl)-2-oxo-2-{4-[1-(phenethylamino-methyl)-cyclohexyl]-piperazin-1-yl}-ethyl)-propionamide
    Show/Hide
Structure
Formula
C31H43Cl2N5O2
Molecular Weight
588.624
Canonical SMILES
NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)C1(CNCCc2ccccc2)CCCCC1
    Show/Hide
InChI
InChI=1S/C31H43Cl2N5O2/c32-26-10-9-25(27(33)22-26)21-28(36-29(39)11-15-34)30(40)37-17-19-38(20-18-37)31(13-5-2-6-14-31)23-35-16-12-24-7-3-1-4-8-24/h1,3-4,7-10,22,28,35H,2,5-6,11-21,23,34H2,(H,36,39)/t28-/m1/s1
    Show/Hide
InChIKey
AJQRPIIDOYMRCS-MUUNZHRXSA-N
Physicochemical Property
logP
4.0489
Rotatable Bonds
12
Heavy Atom Count
40
Polar Areas
90.7
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44397281
ChEMBL ID
CHEMBL365237
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01325, Melanocortin receptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 3200 nM
   TI
   LI
   LO
   TS
Protein ID: PT00914, Melanocortin receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 11 nM
   TI
   LI
   LO
   TS
Protein ID: PT01804, Melanocortin receptor 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 1200 nM
   TI
   LI
   LO
   TS