General Information of the Compound
Compound ID
CP0448856
Compound Name
1-Phenyl-3-(4-pyridin-2-yl-thiazol-2-yl)-urea
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Synonyms
1-Phenyl-3-(4-pyridin-2-yl-thiazol-2-yl)-urea
1-Phenyl-3-[4-(2-pyridyl)-2-thiazolyl]urea
AKOS028168115
BDBM50097425
CHEMBL164422
TCMDC-143133
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Structure
Formula
C15H12N4OS
Molecular Weight
296.355
Canonical SMILES
O=C(Nc1nc(cs1)-c1ccccn1)Nc1ccccc1
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InChI
InChI=1S/C15H12N4OS/c20-14(17-11-6-2-1-3-7-11)19-15-18-13(10-21-15)12-8-4-5-9-16-12/h1-10H,(H2,17,18,19,20)
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InChIKey
SDGJJDKFCDDMKK-UHFFFAOYSA-N
Physicochemical Property
logP
3.8491
Rotatable Bonds
3
Heavy Atom Count
21
Polar Areas
66.91
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
21

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10590030
SID: 15618980
ChEMBL ID
CHEMBL164422
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 5000 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( 1-Phenyl-3-(4-pyridin-2-yl-thiazol-2-yl)-urea )
Drug Name 1-Phenyl-3-(4-pyridin-2-yl-thiazol-2-yl)-urea
Target(s)
Adenosine A2a receptor (ADORA2A)
Inhibitor