General Information of the Compound
Compound ID
CP0447737
Compound Name
5-(3-chloro-4-propan-2-yloxyphenyl)-N-(1,2,3,6-tetrahydropyridin-4-yl)-1,3,4-thiadiazol-2-amine
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Structure
Formula
C16H19ClN4OS
Molecular Weight
350.875
Canonical SMILES
CC(C)Oc1ccc(cc1Cl)-c1nnc(NC2=CCNCC2)s1
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InChI
InChI=1S/C16H19ClN4OS/c1-10(2)22-14-4-3-11(9-13(14)17)15-20-21-16(23-15)19-12-5-7-18-8-6-12/h3-5,9-10,18H,6-8H2,1-2H3,(H,19,21)
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InChIKey
QOMHWECRSMWWHZ-UHFFFAOYSA-N
Physicochemical Property
logP
3.9348
Rotatable Bonds
5
Heavy Atom Count
23
Polar Areas
59.07
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127028148
ChEMBL ID
CHEMBL3770305
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01688, Sphingosine 1-phosphate receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000466 McA-RH7777 Rattus norvegicus (Rat)  1
1
EC50 = 1584.89 nM
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