General Information of the Compound
Compound ID
CP0442115
Compound Name
(3S)-4-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoic acid
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Structure
Formula
C60H82N12O14
Molecular Weight
1195.386
Canonical SMILES
CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
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InChI
InChI=1S/C60H82N12O14/c1-33(2)48(68-55(81)43(31-47(75)76)67-59(85)50(36(6)73)70-57(83)45-25-17-27-72(45)60(86)49(34(3)4)69-53(79)40(61)28-37-18-10-7-11-19-37)58(84)63-32-46(74)71-26-16-24-44(71)56(82)66-42(30-39-22-14-9-15-23-39)54(80)64-35(5)52(78)65-41(51(62)77)29-38-20-12-8-13-21-38/h7-15,18-23,33-36,40-45,48-50,73H,16-17,24-32,61H2,1-6H3,(H2,62,77)(H,63,84)(H,64,80)(H,65,78)(H,66,82)(H,67,85)(H,68,81)(H,69,79)(H,70,83)(H,75,76)/t35-,36+,40-,41-,42-,43-,44-,45-,48-,49-,50-/m0/s1
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InChIKey
BAYUFTCZBUGKHJ-KTHKGSMISA-N
Physicochemical Property
logP
-1.7937
Rotatable Bonds
30
Heavy Atom Count
86
Polar Areas
400.06
Hydrogen Bond Donor Count
12
Hydrogen Bond Acceptor Count
14
Complexity
86

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11434781
SID: 16532183
ChEMBL ID
CHEMBL376719
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 707.95 nM
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