General Information of the Compound
Compound ID
CP0441219
Compound Name
2-[(4-fluorophenyl)methylamino]-6-(5-methyl-1H-pyrazole-3-carbonyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carbonitrile
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Structure
Formula
C20H18FN5OS
Molecular Weight
395.463
Canonical SMILES
Cc1cc([nH]n1)C(=O)N1CCc2c(C1)sc(NCc1ccc(F)cc1)c2C#N
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InChI
InChI=1S/C20H18FN5OS/c1-12-8-17(25-24-12)20(27)26-7-6-15-16(9-22)19(28-18(15)11-26)23-10-13-2-4-14(21)5-3-13/h2-5,8,23H,6-7,10-11H2,1H3,(H,24,25)
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InChIKey
FSTOLTCZGBUNAF-UHFFFAOYSA-N
Physicochemical Property
logP
3.601
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
84.81
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118735961
ChEMBL ID
CHEMBL3422877
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01994, Metabotropic glutamate receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000447 Chem-3 Mus musculus (Mouse)  1
1
IC50 = 2450 nM
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