General Information of the Compound
Compound ID
CP0440879
Compound Name
(4aS)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4a-[(4-methylpiperazin-1-yl)methyl]-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
    Show/Hide
Structure
Formula
C32H40FN5O2S
Molecular Weight
577.77
Canonical SMILES
CN1CCN(C[C@@]23CN(CCC2=Cc2c(C3)cnn2-c2ccc(F)cc2)S(=O)(=O)c2ccc(cc2)C(C)(C)C)CC1
    Show/Hide
InChI
InChI=1S/C32H40FN5O2S/c1-31(2,3)25-5-11-29(12-6-25)41(39,40)37-14-13-26-19-30-24(21-34-38(30)28-9-7-27(33)8-10-28)20-32(26,23-37)22-36-17-15-35(4)16-18-36/h5-12,19,21H,13-18,20,22-23H2,1-4H3/t32-/m0/s1
    Show/Hide
InChIKey
CRNBLUOPQLCADK-YTTGMZPUSA-N
Physicochemical Property
logP
4.5768
Rotatable Bonds
5
Heavy Atom Count
41
Polar Areas
61.68
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44454802
ChEMBL ID
CHEMBL403334
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000229 SW1353 Homo sapiens (Human)  1
1
Ki = 85 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 6.7 nM