General Information of the Compound
Compound ID
CP0440411
Compound Name
7-[2-[4-[[benzyl-[2-(4-oxo-2-phenylchromen-7-yl)oxyethyl]amino]methyl]triazol-1-yl]ethoxy]-2-phenylchromen-4-one
    Show/Hide
Structure
Formula
C44H36N4O6
Molecular Weight
716.794
Canonical SMILES
O=c1cc(oc2cc(OCCN(Cc3cn(CCOc4ccc5c(c4)oc(cc5=O)-c4ccccc4)nn3)Cc3ccccc3)ccc12)-c1ccccc1
    Show/Hide
InChI
InChI=1S/C44H36N4O6/c49-39-26-41(32-12-6-2-7-13-32)53-43-24-35(16-18-37(39)43)51-22-20-47(28-31-10-4-1-5-11-31)29-34-30-48(46-45-34)21-23-52-36-17-19-38-40(50)27-42(54-44(38)25-36)33-14-8-3-9-15-33/h1-19,24-27,30H,20-23,28-29H2
    Show/Hide
InChIKey
PRPJLTBJAUNPBJ-UHFFFAOYSA-N
Physicochemical Property
logP
7.9851
Rotatable Bonds
14
Heavy Atom Count
54
Polar Areas
112.83
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
10
Complexity
54

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 89784717
ChEMBL ID
CHEMBL4540601
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01546, ATP-dependent translocase ABCB1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000350 MDA435/LCC6MDR1 Homo sapiens (Human)  1
1
EC50 = 896.7 nM
   TI
   LI
   LO
   TS
Protein ID: PT02718, Broad substrate specificity ATP-binding cassette transporter ABCG2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000462 HEKR2 Homo sapiens (Human)  1
1
EC50 = 190 nM
   TI
   LI
   LO
   TS
CL000415 MCF-7 MX100 Homo sapiens (Human)  1
1
EC50 = 280 nM
   TI
   LI
   LO
   TS