General Information of the Compound
Compound ID
CP0439934
Compound Name
4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)but-3-ynyl]piperidin-4-ol
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Structure
Formula
C21H21ClFNO
Molecular Weight
357.856
Canonical SMILES
OC1(CCN(CCC#Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
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InChI
InChI=1S/C21H21ClFNO/c22-19-8-6-18(7-9-19)21(25)12-15-24(16-13-21)14-2-1-3-17-4-10-20(23)11-5-17/h4-11,25H,2,12-16H2
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InChIKey
FCFNEHFCHRJYQM-UHFFFAOYSA-N
Physicochemical Property
logP
4.2043
Rotatable Bonds
3
Heavy Atom Count
25
Polar Areas
23.47
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 18427972
ChEMBL ID
CHEMBL4475451
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  2
1
Kd = 70.79 nM
   TI
   LI
   LO
   TS
2
Ki = 74.13 nM
   TI
   LI
   LO
   TS