General Information of the Compound
Compound ID
CP0439757
Compound Name
N-[[1-(6-aminopyridin-2-yl)piperidin-4-yl]methyl]-4-bromo-3-[(2-chlorobenzoyl)amino]-1H-pyrazole-5-carboxamide
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Structure
Formula
C22H23BrClN7O2
Molecular Weight
532.83
Canonical SMILES
Nc1cccc(n1)N1CCC(CNC(=O)c2n[nH]c(NC(=O)c3ccccc3Cl)c2Br)CC1
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InChI
InChI=1S/C22H23BrClN7O2/c23-18-19(29-30-20(18)28-21(32)14-4-1-2-5-15(14)24)22(33)26-12-13-8-10-31(11-9-13)17-7-3-6-16(25)27-17/h1-7,13H,8-12H2,(H2,25,27)(H,26,33)(H2,28,29,30,32)
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InChIKey
WFFSPTMHWZWRHQ-UHFFFAOYSA-N
Physicochemical Property
logP
3.7015
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
129.03
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
6
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 23631903
SID: 46493439
ChEMBL ID
CHEMBL243680
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01032, B1 bradykinin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000411 IMR-90 Homo sapiens (Human)  1
1
IC50 = 13 nM
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