General Information of the Compound
Compound ID
CP0437508
Compound Name
2-{2,5-Dimethoxy-4-[3-(4-methoxy-phenyl)-propyl]-phenyl}-1-methyl-ethylamine
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Structure
Formula
C21H29NO3
Molecular Weight
343.467
Canonical SMILES
COc1ccc(CCCc2cc(OC)c(CC(C)N)cc2OC)cc1
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InChI
InChI=1S/C21H29NO3/c1-15(22)12-18-14-20(24-3)17(13-21(18)25-4)7-5-6-16-8-10-19(23-2)11-9-16/h8-11,13-15H,5-7,12,22H2,1-4H3
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InChIKey
QQVQBSXATXKAAM-UHFFFAOYSA-N
Physicochemical Property
logP
3.7774
Rotatable Bonds
9
Heavy Atom Count
25
Polar Areas
53.71
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10807330
SID: 15847270
ChEMBL ID
CHEMBL104102
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01492, 5-hydroxytryptamine receptor 2A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3 Mus musculus (Mouse)  1
1
Ki = 28 nM
   TI
   LI
   LO
   TS
Protein ID: PT01480, 5-hydroxytryptamine receptor 2C
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000398 A-9 Mus musculus (Mouse)  1
1
Ki = 24 nM
   TI
   LI
   LO
   TS