General Information of the Compound
Compound ID
CP0437298
Compound Name
methyl 3-[[2-[4-[2-[2-[2-[4-[4-[1-[2-[2-[2-[4-[3-[(3-methoxycarbonylphenyl)methoxy]-4-oxochromen-2-yl]phenoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]phenyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]phenyl]-4-oxochromen-3-yl]oxymethyl]benzoate
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Structure
Formula
C70H64N6O16
Molecular Weight
1245.308
Canonical SMILES
COC(=O)c1cccc(COc2c(oc3ccccc3c2=O)-c2ccc(OCCOCCOCCn3cc(nn3)-c3ccc(cc3)-c3cn(CCOCCOCCOc4ccc(cc4)-c4oc5ccccc5c(=O)c4OCc4cccc(c4)C(=O)OC)nn3)cc2)c1
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InChI
InChI=1S/C70H64N6O16/c1-81-69(79)53-11-7-9-47(41-53)45-89-67-63(77)57-13-3-5-15-61(57)91-65(67)51-21-25-55(26-22-51)87-39-37-85-35-33-83-31-29-75-43-59(71-73-75)49-17-19-50(20-18-49)60-44-76(74-72-60)30-32-84-34-36-86-38-40-88-56-27-23-52(24-28-56)66-68(64(78)58-14-4-6-16-62(58)92-66)90-46-48-10-8-12-54(42-48)70(80)82-2/h3-28,41-44H,29-40,45-46H2,1-2H3
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InChIKey
RIOHEKHDEXVZMU-UHFFFAOYSA-N
Physicochemical Property
logP
10.706
Rotatable Bonds
32
Heavy Atom Count
92
Polar Areas
248.28
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
22
Complexity
92

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155568869
ChEMBL ID
CHEMBL4592756
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01546, ATP-dependent translocase ABCB1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000350 MDA435/LCC6MDR1 Homo sapiens (Human)  1
1
EC50 > 1000 nM
   TI
   LI
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   TS
Protein ID: PT02718, Broad substrate specificity ATP-binding cassette transporter ABCG2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000462 HEKR2 Homo sapiens (Human)  1
1
EC50 = 2.4 nM
   TI
   LI
   LO
   TS
CL000415 MCF-7 MX100 Homo sapiens (Human)  1
1
EC50 = 13.7 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3 Mus musculus (Mouse)  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS