General Information of the Compound
Compound ID
CP0437290
Compound Name
7-[2-[2-[4-[2-(4-oxo-2-phenylchromen-7-yl)oxyethoxymethyl]triazol-1-yl]ethoxy]ethoxy]-2-phenylchromen-4-one
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Structure
Formula
C39H33N3O8
Molecular Weight
671.706
Canonical SMILES
O=c1cc(oc2cc(OCCOCCn3cc(COCCOc4ccc5c(c4)oc(cc5=O)-c4ccccc4)nn3)ccc12)-c1ccccc1
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InChI
InChI=1S/C39H33N3O8/c43-34-23-36(27-7-3-1-4-8-27)49-38-21-30(11-13-32(34)38)47-19-17-45-16-15-42-25-29(40-41-42)26-46-18-20-48-31-12-14-33-35(44)24-37(50-39(33)22-31)28-9-5-2-6-10-28/h1-14,21-25H,15-20,26H2
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InChIKey
FHTZACIJYGMKQR-UHFFFAOYSA-N
Physicochemical Property
logP
6.5161
Rotatable Bonds
15
Heavy Atom Count
50
Polar Areas
128.05
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
11
Complexity
50

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 89784760
ChEMBL ID
CHEMBL4282260
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01546, ATP-dependent translocase ABCB1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000350 MDA435/LCC6MDR1 Homo sapiens (Human)  1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
Protein ID: PT02718, Broad substrate specificity ATP-binding cassette transporter ABCG2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000462 HEKR2 Homo sapiens (Human)  1
1
EC50 = 195 nM
   TI
   LI
   LO
   TS
CL000415 MCF-7 MX100 Homo sapiens (Human)  1
1
EC50 = 308 nM
   TI
   LI
   LO
   TS