General Information of the Compound
Compound ID
CP0436908
Compound Name
5-hydroxy-8-[4-[4-[3-[(E)-hydroxyiminomethyl]pyrazolo[1,5-a]pyridin-5-yl]oxybutyl]piperazin-1-yl]-4H-1,4-benzoxazin-3-one
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Structure
Formula
C24H28N6O5
Molecular Weight
480.525
Canonical SMILES
O\N=C\c1cnn2ccc(OCCCCN3CCN(CC3)c3ccc(O)c4NC(=O)COc34)cc12
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InChI
InChI=1S/C24H28N6O5/c31-21-4-3-19(24-23(21)27-22(32)16-35-24)29-10-8-28(9-11-29)6-1-2-12-34-18-5-7-30-20(13-18)17(14-25-30)15-26-33/h3-5,7,13-15,31,33H,1-2,6,8-12,16H2,(H,27,32)/b26-15+
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InChIKey
AQCPIJGBSDFUKW-CVKSISIWSA-N
Physicochemical Property
logP
2.1601
Rotatable Bonds
8
Heavy Atom Count
35
Polar Areas
124.16
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
10
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137634397
ChEMBL ID
CHEMBL4063145
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 110 nM
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