General Information of the Compound
Compound ID
CP0432376
Compound Name
N-[1-[(5-chloro-2-phenyl-1-benzofuran-7-yl)methyl]-5-methylpyrazol-3-yl]-1-(2,2,2-trifluoroethyl)piperidine-4-carboxamide
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Structure
Formula
C27H26ClF3N4O2
Molecular Weight
530.978
Canonical SMILES
Cc1cc(NC(=O)C2CCN(CC(F)(F)F)CC2)nn1Cc1cc(Cl)cc2cc(oc12)-c1ccccc1
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InChI
InChI=1S/C27H26ClF3N4O2/c1-17-11-24(32-26(36)19-7-9-34(10-8-19)16-27(29,30)31)33-35(17)15-21-13-22(28)12-20-14-23(37-25(20)21)18-5-3-2-4-6-18/h2-6,11-14,19H,7-10,15-16H2,1H3,(H,32,33,36)
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InChIKey
CGDHUGPBAFBGAA-UHFFFAOYSA-N
Physicochemical Property
logP
6.51922
Rotatable Bonds
6
Heavy Atom Count
37
Polar Areas
63.3
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57393868
ChEMBL ID
CHEMBL1915260
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01205, Prostaglandin E2 receptor EP1 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 25.12 nM
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