General Information of the Compound
Compound ID
CP0430653
Compound Name
(S)-6-methyl-1-((3'-methyl-2',5'-dioxo-6,8-dihydrospiro[cyclopenta[g]quinoline-7,4'-imidazolidine]-2-yl)methyl)-1H-imidazo[1,5,4-de]quinoxaline-2,5(4H,6H)-dione
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Structure
Formula
C26H22N6O4
Molecular Weight
482.5
Canonical SMILES
CN1C(=O)NC(=O)[C@@]11Cc2cc3ccc(Cn4c5cccc6N(C)C(=O)Cn(c56)c4=O)nc3cc2C1
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InChI
InChI=1S/C26H22N6O4/c1-29-19-4-3-5-20-22(19)32(13-21(29)33)25(36)31(20)12-17-7-6-14-8-15-10-26(11-16(15)9-18(14)27-17)23(34)28-24(35)30(26)2/h3-9H,10-13H2,1-2H3,(H,28,34,35)/t26-/m0/s1
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InChIKey
NESIWEIPQDJTFW-SANMLTNESA-N
Physicochemical Property
logP
1.3949
Rotatable Bonds
2
Heavy Atom Count
36
Polar Areas
109.54
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46885184
ChEMBL ID
CHEMBL1092883
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  3
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
2
IC50 = 1200 nM
   TI
   LI
   LO
   TS
3
Ki = 3 nM
   TI
   LI
   LO
   TS