General Information of the Compound
Compound ID
CP0430096
Compound Name
N-[2-[3-[[12-chloro-2-(1-methyl-2-oxo-4-sulfanylidenepyrimidin-5-yl)-6-thia-4-azatricyclo[8.4.0.03,7]tetradeca-1(10),3(7),4,8,11,13-hexaen-5-yl]amino]propanoylamino]ethyl]-3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)propanamide
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Structure
Formula
C36H36BClF2N8O3S2
Molecular Weight
777.132
Canonical SMILES
Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCNC(=O)CCNc3nc4C(c5ccc(Cl)cc5C=Cc4s3)c3cn(C)c(=O)[nH]c3=S)=[N+]1[B-]2(F)F
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InChI
InChI=1S/C36H36BClF2N8O3S2/c1-20-16-21(2)47-28(20)18-25-7-6-24(48(25)37(47,39)40)8-11-30(49)41-14-15-42-31(50)12-13-43-35-44-33-29(53-35)10-4-22-17-23(38)5-9-26(22)32(33)27-19-46(3)36(51)45-34(27)52/h4-7,9-10,16-19,32H,8,11-15H2,1-3H3,(H,41,49)(H,42,50)(H,43,44)(H,45,51,52)
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InChIKey
OAWVBAUEBVZOAN-UHFFFAOYSA-N
Physicochemical Property
logP
5.75043
Rotatable Bonds
11
Heavy Atom Count
53
Polar Areas
128.85
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
53

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145962035
ChEMBL ID
CHEMBL4129692
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04714, P2Y purinoceptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000094 1321N1 Homo sapiens (Human)  1
1
Kd = 12302.69 nM
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