General Information of the Compound
Compound ID
CP0429979
Compound Name
3-((5'-chloro-3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1-cyclohexyl-1-hydroxyurea
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Structure
Formula
C21H22ClF2N7O2
Molecular Weight
477.903
Canonical SMILES
Cn1nnc(n1)-c1c(F)cc(Cl)cc1-c1cnc(CNC(=O)N(O)C2CCCCC2)c(F)c1
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InChI
InChI=1S/C21H22ClF2N7O2/c1-30-28-20(27-29-30)19-15(8-13(22)9-17(19)24)12-7-16(23)18(25-10-12)11-26-21(32)31(33)14-5-3-2-4-6-14/h7-10,14,33H,2-6,11H2,1H3,(H,26,32)
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InChIKey
JMQKQWJOUXTMOM-UHFFFAOYSA-N
Physicochemical Property
logP
4.1042
Rotatable Bonds
5
Heavy Atom Count
33
Polar Areas
109.06
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46230989
ChEMBL ID
CHEMBL596623
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01032, B1 bradykinin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000411 IMR-90 Homo sapiens (Human)  1
1
IC50 = 3.9 nM
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