General Information of the Compound
Compound ID
CP0429544
Compound Name
2,4-dimethyl-1,3-dioxo-N-[4-(1,3-thiazol-2-yl)phenyl]-7,8-dihydro-6H-purino[7,8-a]pyrrole-8-carboxamide
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Structure
Formula
C20H18N6O3S
Molecular Weight
422.47
Canonical SMILES
Cn1c2nc3CCC(C(=O)Nc4ccc(cc4)-c4nccs4)n3c2c(=O)n(C)c1=O
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InChI
InChI=1S/C20H18N6O3S/c1-24-16-15(19(28)25(2)20(24)29)26-13(7-8-14(26)23-16)17(27)22-12-5-3-11(4-6-12)18-21-9-10-30-18/h3-6,9-10,13H,7-8H2,1-2H3,(H,22,27)
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InChIKey
RUOXGKMKUPIYHN-UHFFFAOYSA-N
Physicochemical Property
logP
1.6832
Rotatable Bonds
3
Heavy Atom Count
30
Polar Areas
103.81
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
9
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137661947
ChEMBL ID
CHEMBL4102043
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04895, Protein-serine O-palmitoleoyltransferase porcupine
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 42 nM
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