General Information of the Compound
Compound ID
CP0429301
Compound Name
N-[2-(2,5-difluorophenoxy)ethyl]-6-fluoro-1,1-dioxo-3,4-dihydro-2H-thiochromen-4-amine;hydrochloride
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Structure
Formula
C17H17ClF3NO3S
Molecular Weight
407.841
Canonical SMILES
Cl.Fc1ccc(F)c(OCCNC2CCS(=O)(=O)c3ccc(F)cc23)c1
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InChI
InChI=1S/C17H16F3NO3S.ClH/c18-11-2-4-17-13(9-11)15(5-8-25(17,22)23)21-6-7-24-16-10-12(19)1-3-14(16)20;/h1-4,9-10,15,21H,5-8H2;1H
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InChIKey
PDBDMHJMLRABLU-UHFFFAOYSA-N
Physicochemical Property
logP
3.4128
Rotatable Bonds
5
Heavy Atom Count
26
Polar Areas
55.4
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145967562
ChEMBL ID
CHEMBL4218841
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01004, Alpha-1D adrenergic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 12 nM
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