General Information of the Compound
Compound ID
CP0424963
Compound Name
(3S)-4-[[(2S)-1-[[2-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrazolidin-1-yl]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-[[(2S,3R)-3-hydroxy-2-[[(2S)-pyrrolidine-2-carbonyl]amino]butanoyl]amino]-4-oxobutanoic acid
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Structure
Formula
C45H63N11O12
Molecular Weight
950.064
Canonical SMILES
CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1)[C@@H](C)O)C(=O)NCC(=O)N1CCCN1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
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InChI
InChI=1S/C45H63N11O12/c1-25(2)36(53-42(65)33(23-35(59)60)51-44(67)37(27(4)57)54-40(63)30-17-11-18-47-30)43(66)48-24-34(58)55-19-12-20-56(55)45(68)52-32(22-29-15-9-6-10-16-29)41(64)49-26(3)39(62)50-31(38(46)61)21-28-13-7-5-8-14-28/h5-10,13-16,25-27,30-33,36-37,47,57H,11-12,17-24H2,1-4H3,(H2,46,61)(H,48,66)(H,49,64)(H,50,62)(H,51,67)(H,52,68)(H,53,65)(H,54,63)(H,59,60)/t26-,27+,30-,31-,32-,33-,36-,37-/m0/s1
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InChIKey
OUHNKVXUUACOBK-UEBUATRSSA-N
Physicochemical Property
logP
-2.6918
Rotatable Bonds
23
Heavy Atom Count
68
Polar Areas
339.9
Hydrogen Bond Donor Count
11
Hydrogen Bond Acceptor Count
12
Complexity
68

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11423175
SID: 16519729
ChEMBL ID
CHEMBL374579
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 4466.84 nM
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