General Information of the Compound
Compound ID
CP0423108
Compound Name
2-{4-[2-Amino-3-(4-fluoro-phenyl)-propionyl]-3-[2-(pyridin-2-ylamino)-ethyl]-piperazin-1-yl}-N-methyl-3-naphthalen-2-yl-propionamide
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Structure
Formula
C34H37FN6O3
Molecular Weight
596.707
Canonical SMILES
CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCNc2ccccn2)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
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InChI
InChI=1S/C34H37FN6O3/c1-37-32(42)30(22-24-9-12-25-6-2-3-7-26(25)20-24)41-19-18-40(33(43)28(36)21-23-10-13-27(35)14-11-23)29(34(41)44)15-17-39-31-8-4-5-16-38-31/h2-14,16,20,28-30H,15,17-19,21-22,36H2,1H3,(H,37,42)(H,38,39)/t28-,29+,30+/m1/s1
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InChIKey
OEIGIBOHBGEWLY-NGDRWEMDSA-N
Physicochemical Property
logP
3.1426
Rotatable Bonds
11
Heavy Atom Count
44
Polar Areas
120.66
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
44

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25133903
SID: 56458441
ChEMBL ID
CHEMBL445009
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01325, Melanocortin receptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 8734 nM
   TI
   LI
   LO
   TS
Protein ID: PT00914, Melanocortin receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 167 nM
   TI
   LI
   LO
   TS
2
Ki = 556 nM
   TI
   LI
   LO
   TS
Protein ID: PT00911, Melanocyte-stimulating hormone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 4469 nM
   TI
   LI
   LO
   TS