General Information of the Compound
Compound ID
CP0422595
Compound Name
4-[(1R,5S)-3-(4-chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]-1-(4-fluorophenyl)butan-1-one
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Structure
Formula
C23H25ClFNO2
Molecular Weight
401.909
Canonical SMILES
OC1(C[C@@H]2CC[C@H](C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
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InChI
InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2/t20-,21+,23?
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InChIKey
CXQUOFVDYCOSEZ-TYABSZSSSA-N
Physicochemical Property
logP
4.9566
Rotatable Bonds
6
Heavy Atom Count
28
Polar Areas
40.54
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11486446
ChEMBL ID
CHEMBL4451384
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  2
1
Kd = 0.05495 nM
   TI
   LI
   LO
   TS
2
Ki = 0.05248 nM
   TI
   LI
   LO
   TS