General Information of the Compound
Compound ID
CP0420857
Compound Name
CHEMBL4521282
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Formula
C16H11N3O
Molecular Weight
261.284
Canonical SMILES
Cc1ccc2nc3\C(=N/O)c4ccccc4-c3nc2c1
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InChI
InChI=1S/C16H11N3O/c1-9-6-7-12-13(8-9)18-14-10-4-2-3-5-11(10)15(19-20)16(14)17-12/h2-8,20H,1H3/b19-15-
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InChIKey
APPUPKYUHWUPCJ-CYVLTUHYSA-N
Physicochemical Property
logP
3.14522
Rotatable Bonds
0
Heavy Atom Count
20
Polar Areas
58.37
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
20

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4521282
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00998, Mitogen-activated protein kinase 10
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Kd = 340 nM
   TI
   LI
   LO
   TS
Protein ID: PT00863, Mitogen-activated protein kinase 8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Kd = 580 nM
   TI
   LI
   LO
   TS
Protein ID: PT00872, Mitogen-activated protein kinase 9
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Kd = 840 nM
   TI
   LI
   LO
   TS