General Information of the Compound
Compound ID
CP0420615
Compound Name
2-hydroxy-N-(2-morpholin-4-ylethyl)-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamide
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Structure
Formula
C25H24N2O5S
Molecular Weight
464.543
Canonical SMILES
Oc1cc(ccc1C(=O)NCCN1CCOCC1)-c1ccc(s1)-c1ccc2C(=O)OCc2c1
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InChI
InChI=1S/C25H24N2O5S/c28-21-14-17(2-4-20(21)24(29)26-7-8-27-9-11-31-12-10-27)23-6-5-22(33-23)16-1-3-19-18(13-16)15-32-25(19)30/h1-6,13-14,28H,7-12,15H2,(H,26,29)
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InChIKey
VQCQVBZWNWRXKJ-UHFFFAOYSA-N
Physicochemical Property
logP
3.5201
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
88.1
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127025717
ChEMBL ID
CHEMBL3752319
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05158, Perforin-1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 = 12750 nM
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