General Information of the Compound
Compound ID
CP0412852
Compound Name
(4S,4aR,7aS,12bR)-4a,9-dihydroxy-3-(4-phenylbutyl)-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
    Show/Hide
Structure
Formula
C26H29NO4
Molecular Weight
419.521
Canonical SMILES
Oc1ccc2C[C@@H]3N(CCCCc4ccccc4)CC[C@]45[C@H](Oc1c24)C(=O)CC[C@]35O
    Show/Hide
InChI
InChI=1S/C26H29NO4/c28-19-10-9-18-16-21-26(30)12-11-20(29)24-25(26,22(18)23(19)31-24)13-15-27(21)14-5-4-8-17-6-2-1-3-7-17/h1-3,6-7,9-10,21,24,28,30H,4-5,8,11-16H2/t21-,24+,25+,26-/m0/s1
    Show/Hide
InChIKey
DZVCLDCCKMGUGY-WSZJRCBQSA-N
Physicochemical Property
logP
3.1383
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
70
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 122177873
ChEMBL ID
CHEMBL3577590
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03041, Toll-like receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000214 BV-2 Mus musculus (Mouse)  1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS