General Information of the Compound
Compound ID
CP0399209
Compound Name
1-[(5-chloro-2-propan-2-yl-1-benzofuran-7-yl)methyl]-5-methyl-N-morpholin-4-ylpyrazole-3-carboxamide
    Show/Hide
Structure
Formula
C21H25ClN4O3
Molecular Weight
416.909
Canonical SMILES
CC(C)c1cc2cc(Cl)cc(Cn3nc(cc3C)C(=O)NN3CCOCC3)c2o1
    Show/Hide
InChI
InChI=1S/C21H25ClN4O3/c1-13(2)19-11-15-9-17(22)10-16(20(15)29-19)12-26-14(3)8-18(23-26)21(27)24-25-4-6-28-7-5-25/h8-11,13H,4-7,12H2,1-3H3,(H,24,27)
    Show/Hide
InChIKey
YTWIMDDIONZBBG-UHFFFAOYSA-N
Physicochemical Property
logP
3.73982
Rotatable Bonds
5
Heavy Atom Count
29
Polar Areas
72.53
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 24784840
SID: 49709263
ChEMBL ID
CHEMBL1915251
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01205, Prostaglandin E2 receptor EP1 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 50.12 nM
   TI
   LI
   LO
   TS