General Information of the Compound
Compound ID
CP0393318
Compound Name
[2-[[5-[(2S,3R,4R,5S,6R)-5-fluoro-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]-4-methoxy-2-methylphenyl]methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]-(1,3-thiazol-2-yl)methanone
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Structure
Formula
C26H29FN2O6S2
Molecular Weight
548.658
Canonical SMILES
COc1cc(C)c(Cc2cc3CN(CCc3s2)C(=O)c2nccs2)cc1[C@@H]1O[C@H](CO)[C@@H](F)[C@H](O)[C@H]1O
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InChI
InChI=1S/C26H29FN2O6S2/c1-13-7-18(34-2)17(24-23(32)22(31)21(27)19(12-30)35-24)10-14(13)8-16-9-15-11-29(5-3-20(15)37-16)26(33)25-28-4-6-36-25/h4,6-7,9-10,19,21-24,30-32H,3,5,8,11-12H2,1-2H3/t19-,21-,22+,23-,24+/m1/s1
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InChIKey
BLFZECRQISKCID-ZXGKGEBGSA-N
Physicochemical Property
logP
2.80302
Rotatable Bonds
6
Heavy Atom Count
37
Polar Areas
112.35
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
9
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137498479
ChEMBL ID
CHEMBL4285963
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03804, Sodium/glucose cotransporter 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 376.1 nM
   TI
   LI
   LO
   TS
Protein ID: PT02415, Sodium/glucose cotransporter 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 23.2 nM
   TI
   LI
   LO
   TS