General Information of the Compound
Compound ID
CP0391976
Compound Name
(S)-3-[(4'-Methoxy-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carboxylic acid methyl-((R)-1-methyl-pyrrolidin-3-yl)-amide
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Structure
Formula
C26H34N4O3
Molecular Weight
450.583
Canonical SMILES
COc1ccc(cc1)-c1ccc(cc1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N(C)[C@@H]1CCN(C)C1
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InChI
InChI=1S/C26H34N4O3/c1-27-15-13-22(17-27)29(3)26(32)30-16-14-23(18-30)28(2)25(31)21-7-5-19(6-8-21)20-9-11-24(33-4)12-10-20/h5-12,22-23H,13-18H2,1-4H3/t22-,23+/m1/s1
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InChIKey
XQHCATPGSUBVRY-PKTZIBPZSA-N
Physicochemical Property
logP
3.2644
Rotatable Bonds
5
Heavy Atom Count
33
Polar Areas
56.33
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44397497
ChEMBL ID
CHEMBL188206
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 5 nM
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