General Information of the Compound
Compound ID
CP0390396
Compound Name
US8853203, 99h
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Structure
Formula
C24H21FN6O
Molecular Weight
428.471
Canonical SMILES
Fc1ccc(cn1)-c1cccc2C3=CC(=NCC(=O)N3CCc12)n1cnc(n1)C1CCC1
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InChI
InChI=1S/C24H21FN6O/c25-21-8-7-16(12-26-21)17-5-2-6-19-18(17)9-10-30-20(19)11-22(27-13-23(30)32)31-14-28-24(29-31)15-3-1-4-15/h2,5-8,11-12,14-15H,1,3-4,9-10,13H2
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InChIKey
RTJVSODYBWREQD-UHFFFAOYSA-N
Physicochemical Property
logP
3.4327
Rotatable Bonds
2
Heavy Atom Count
32
Polar Areas
76.27
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 73336216
ChEMBL ID
CHEMBL3702464
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00854, Metabotropic glutamate receptor 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000101 L-M(TK-) Mus musculus (Mouse)  1
1
IC50 = 38 nM
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