General Information of the Compound
Compound ID
CP0390135
Compound Name
(S)-3'-methyl-2-((2-oxo-3,4-dihydroquinolin-1(2H)-yl)methyl)-6,8-dihydrospiro[cyclopenta[g]quinoline-7,4'-imidazolidine]-2',5'-dione
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Structure
Formula
C25H22N4O3
Molecular Weight
426.476
Canonical SMILES
CN1C(=O)NC(=O)[C@@]11Cc2cc3ccc(CN4C(=O)CCc5ccccc45)nc3cc2C1
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InChI
InChI=1S/C25H22N4O3/c1-28-24(32)27-23(31)25(28)12-17-10-16-6-8-19(26-20(16)11-18(17)13-25)14-29-21-5-3-2-4-15(21)7-9-22(29)30/h2-6,8,10-11H,7,9,12-14H2,1H3,(H,27,31,32)/t25-/m0/s1
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InChIKey
YXAAGFHRLUCKJU-VWLOTQADSA-N
Physicochemical Property
logP
2.7332
Rotatable Bonds
2
Heavy Atom Count
32
Polar Areas
82.61
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46885133
ChEMBL ID
CHEMBL1090846
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  3
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
2
IC50 = 850 nM
   TI
   LI
   LO
   TS
3
Ki = 8.9 nM
   TI
   LI
   LO
   TS