General Information of the Compound
Compound ID
CP0389686
Compound Name
N-[5-[5-(2-methyl-1-oxo-3H-isoindol-5-yl)thiophen-2-yl]pyridin-3-yl]-5-(1,2-oxazol-5-yl)thiophene-2-sulfonamide
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Structure
Formula
C25H18N4O4S3
Molecular Weight
534.644
Canonical SMILES
CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2ccc(s2)-c2ccno2)c1
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InChI
InChI=1S/C25H18N4O4S3/c1-29-14-17-10-15(2-3-19(17)25(29)30)21-4-5-22(34-21)16-11-18(13-26-12-16)28-36(31,32)24-7-6-23(35-24)20-8-9-27-33-20/h2-13,28H,14H2,1H3
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InChIKey
JCCVLAGTNBSUSM-UHFFFAOYSA-N
Physicochemical Property
logP
5.58
Rotatable Bonds
6
Heavy Atom Count
36
Polar Areas
105.4
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 73296702
ChEMBL ID
CHEMBL4160931
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05158, Perforin-1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 = 7100 nM
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