General Information of the Compound
Compound ID
CP0387422
Compound Name
(R)-N-(1-(5-(5-chloro-2-(2,2-difluoroethoxy)-3-fluorophenyl)-3-fluoropyridin-2-yl)ethyl)-1-ethyl-2-(2,2,2-trifluoroacetyl)hydrazinecarboxamide
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Structure
Formula
C20H18ClF7N4O3
Molecular Weight
530.828
Canonical SMILES
CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(cc1F)-c1cc(Cl)cc(F)c1OCC(F)F
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InChI
InChI=1S/C20H18ClF7N4O3/c1-3-32(31-18(33)20(26,27)28)19(34)30-9(2)16-13(22)4-10(7-29-16)12-5-11(21)6-14(23)17(12)35-8-15(24)25/h4-7,9,15H,3,8H2,1-2H3,(H,30,34)(H,31,33)/t9-/m1/s1
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InChIKey
NRUMXOPTHWVHMM-SECBINFHSA-N
Physicochemical Property
logP
5.0101
Rotatable Bonds
7
Heavy Atom Count
35
Polar Areas
83.56
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46216845
SID: 96071239
ChEMBL ID
CHEMBL599780
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01032, B1 bradykinin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000411 IMR-90 Homo sapiens (Human)  1
1
IC50 = 1.8 nM
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