General Information of the Compound
Compound ID
CP0383561
Compound Name
(9S,12S,15S,18R,21S)-15-[3-(diaminomethylideneamino)propyl]-21-(1H-imidazol-5-ylmethyl)-12-(1H-indol-3-ylmethyl)-18-(naphthalen-2-ylmethyl)-7,11,14,17,20,23-hexaoxo-6,10,13,16,19,22-hexazaspiro[4.18]tricosane-9-carboxamide
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Structure
Formula
C46H55N13O7
Molecular Weight
902.03
Canonical SMILES
NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O
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InChI
InChI=1S/C46H55N13O7/c47-39(61)34-22-38(60)59-46(15-5-6-16-46)44(66)58-37(21-30-24-50-25-53-30)43(65)56-35(19-26-13-14-27-8-1-2-9-28(27)18-26)41(63)54-33(12-7-17-51-45(48)49)40(62)57-36(42(64)55-34)20-29-23-52-32-11-4-3-10-31(29)32/h1-4,8-11,13-14,18,23-25,33-37,52H,5-7,12,15-17,19-22H2,(H2,47,61)(H,50,53)(H,54,63)(H,55,64)(H,56,65)(H,57,62)(H,58,66)(H,59,60)(H4,48,49,51)/t33-,34-,35+,36-,37-/m0/s1
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InChIKey
MSRUJRYKGIBVTG-GJOOVXBSSA-N
Physicochemical Property
logP
0.07737
Rotatable Bonds
11
Heavy Atom Count
66
Polar Areas
324.06
Hydrogen Bond Donor Count
12
Hydrogen Bond Acceptor Count
9
Complexity
66

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145973975
ChEMBL ID
CHEMBL4216654
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01325, Melanocortin receptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 1.9 nM
   TI
   LI
   LO
   TS
2
IC50 = 16 nM
   TI
   LI
   LO
   TS
Protein ID: PT00914, Melanocortin receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 110 nM
   TI
   LI
   LO
   TS
2
IC50 = 73 nM
   TI
   LI
   LO
   TS
Protein ID: PT01804, Melanocortin receptor 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 96 nM
   TI
   LI
   LO
   TS
2
IC50 = 160 nM
   TI
   LI
   LO
   TS
Protein ID: PT00911, Melanocyte-stimulating hormone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 14 nM
   TI
   LI
   LO
   TS
2
IC50 = 290 nM
   TI
   LI
   LO
   TS