General Information of the Compound
Compound ID
CP0382626
Compound Name
N,1-dibenzyl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamide
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Structure
Formula
C24H25N3O
Molecular Weight
371.484
Canonical SMILES
O=C(NCc1ccccc1)N1CCN(Cc2ccccc2)c2ccccc2C1
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InChI
InChI=1S/C24H25N3O/c28-24(25-17-20-9-3-1-4-10-20)27-16-15-26(18-21-11-5-2-6-12-21)23-14-8-7-13-22(23)19-27/h1-14H,15-19H2,(H,25,28)
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InChIKey
GYZMZXNNALBNTL-UHFFFAOYSA-N
Physicochemical Property
logP
4.4186
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
35.58
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 134152745
ChEMBL ID
CHEMBL3979642
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03095, Voltage-dependent T-type calcium channel subunit alpha-1G
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 305 nM
   TI
   LI
   LO
   TS
Protein ID: PT04557, Voltage-dependent T-type calcium channel subunit alpha-1H
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 392 nM
   TI
   LI
   LO
   TS
Protein ID: PT02881, Voltage-dependent T-type calcium channel subunit alpha-1I
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 214 nM
   TI
   LI
   LO
   TS