General Information of the Compound
Compound ID
CP0381135
Compound Name
N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(6-oxo-1H-pyridazin-5-yl)piperidine-1-carboxamide
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Structure
Formula
C24H26F5N5O3
Molecular Weight
527.494
Canonical SMILES
Fc1cccc([C@@H]2CC[C@@H](NC(=O)N3CCC(CC3)c3ccn[nH]c3=O)C(=O)N(CC(F)(F)F)C2)c1F
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InChI
InChI=1S/C24H26F5N5O3/c25-18-3-1-2-16(20(18)26)15-4-5-19(22(36)34(12-15)13-24(27,28)29)31-23(37)33-10-7-14(8-11-33)17-6-9-30-32-21(17)35/h1-3,6,9,14-15,19H,4-5,7-8,10-13H2,(H,31,37)(H,32,35)/t15-,19-/m1/s1
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InChIKey
FJPBDMFBVGVUFP-DNVCBOLYSA-N
Physicochemical Property
logP
3.2742
Rotatable Bonds
4
Heavy Atom Count
37
Polar Areas
98.4
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11432505
SID: 16529896
ChEMBL ID
CHEMBL570793
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  3
1
IC50 = 44 nM
   TI
   LI
   LO
   TS
2
IC50 = 112 nM
   TI
   LI
   LO
   TS
3
Ki = 10 nM
   TI
   LI
   LO
   TS