General Information of the Compound
Compound ID
CP0381134
Compound Name
N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-1H-pyridin-3-yl)piperidine-1-carboxamide
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Structure
Formula
C25H27F5N4O3
Molecular Weight
526.506
Canonical SMILES
Fc1cccc([C@@H]2CC[C@@H](NC(=O)N3CCC(CC3)c3ccc[nH]c3=O)C(=O)N(CC(F)(F)F)C2)c1F
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InChI
InChI=1S/C25H27F5N4O3/c26-19-5-1-3-17(21(19)27)16-6-7-20(23(36)34(13-16)14-25(28,29)30)32-24(37)33-11-8-15(9-12-33)18-4-2-10-31-22(18)35/h1-5,10,15-16,20H,6-9,11-14H2,(H,31,35)(H,32,37)/t16-,20-/m1/s1
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InChIKey
SRNUFLPARKRBGV-OXQOHEQNSA-N
Physicochemical Property
logP
3.8792
Rotatable Bonds
4
Heavy Atom Count
37
Polar Areas
85.51
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45487023
ChEMBL ID
CHEMBL583547
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 100 nM
   TI
   LI
   LO
   TS