General Information of the Compound
Compound ID
CP0378635
Compound Name
(R)-N-((R)-7-((tert-butylamino)methyl)chroman-4-yl)-3-(4-tert-butylphenylsulfonamido)-3-phenylpropanamide
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Structure
Formula
C33H43N3O4S
Molecular Weight
577.791
Canonical SMILES
CC(C)(C)NCc1ccc2[C@@H](CCOc2c1)NC(=O)C[C@@H](NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccccc1
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InChI
InChI=1S/C33H43N3O4S/c1-32(2,3)25-13-15-26(16-14-25)41(38,39)36-29(24-10-8-7-9-11-24)21-31(37)35-28-18-19-40-30-20-23(12-17-27(28)30)22-34-33(4,5)6/h7-17,20,28-29,34,36H,18-19,21-22H2,1-6H3,(H,35,37)/t28-,29-/m1/s1
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InChIKey
DTNPKCVNXKBVJP-FQLXRVMXSA-N
Physicochemical Property
logP
5.9219
Rotatable Bonds
9
Heavy Atom Count
41
Polar Areas
96.53
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 16221164
SID: 24903643
ChEMBL ID
CHEMBL413786
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01032, B1 bradykinin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000389 CHO-DXB11 Cricetulus griseus (Chinese hamster)  2
1
IC50 = 60.9 nM
   TI
   LI
   LO
   TS
2
Ki = 24.8 nM
   TI
   LI
   LO
   TS