General Information of the Compound
Compound ID
CP0376669
Compound Name
N-[(1S)-3-[2'-(2-methylbenzimidazol-1-yl)spiro[7-azabicyclo[2.2.1]heptane-2,1'-cyclopropane]-7-yl]-1-phenylpropyl]cyclobutanecarboxamide
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Structure
Formula
C30H36N4O
Molecular Weight
468.645
Canonical SMILES
Cc1nc2ccccc2n1C1CC11CC2CCC1N2CC[C@H](NC(=O)C1CCC1)c1ccccc1
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InChI
InChI=1S/C30H36N4O/c1-20-31-25-12-5-6-13-26(25)34(20)28-19-30(28)18-23-14-15-27(30)33(23)17-16-24(21-8-3-2-4-9-21)32-29(35)22-10-7-11-22/h2-6,8-9,12-13,22-24,27-28H,7,10-11,14-19H2,1H3,(H,32,35)/t23?,24-,27?,28?,30?/m0/s1
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InChIKey
BJENQUZWMHDDIJ-GVCKKYRWSA-N
Physicochemical Property
logP
5.56032
Rotatable Bonds
7
Heavy Atom Count
35
Polar Areas
50.16
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44415820
ChEMBL ID
CHEMBL213914
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 6 nM
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