General Information of the Compound
Compound ID
CP0374119
Compound Name
N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-2-oxospiro[1H-3,1-benzoxazine-4,4'-piperidine]-1'-carboxamide
    Show/Hide
Structure
Formula
C27H27F5N4O4
Molecular Weight
566.527
Canonical SMILES
Fc1cccc([C@@H]2CC[C@@H](NC(=O)N3CCC4(CC3)OC(=O)Nc3ccccc43)C(=O)N(CC(F)(F)F)C2)c1F
    Show/Hide
InChI
InChI=1S/C27H27F5N4O4/c28-19-6-3-4-17(22(19)29)16-8-9-21(23(37)36(14-16)15-27(30,31)32)33-24(38)35-12-10-26(11-13-35)18-5-1-2-7-20(18)34-25(39)40-26/h1-7,16,21H,8-15H2,(H,33,38)(H,34,39)/t16-,21-/m1/s1
    Show/Hide
InChIKey
JBIBSZVZIAZPBO-IIBYNOLFSA-N
Physicochemical Property
logP
4.8647
Rotatable Bonds
3
Heavy Atom Count
40
Polar Areas
90.98
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 11555955
SID: 16658125
ChEMBL ID
CHEMBL571459
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  3
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
2
IC50 = 792 nM
   TI
   LI
   LO
   TS
3
Ki = 46 nM
   TI
   LI
   LO
   TS