General Information of the Compound
Compound ID
CP0372068
Compound Name
(R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-yl)-2-(2-oxo-3-(tetrahydro-2H-thiopyran-4-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetamide
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Structure
Formula
C26H27N5O4S
Molecular Weight
505.6
Canonical SMILES
CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4ccccc4n(C4CCSCC4)c3=O)cc2C1
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InChI
InChI=1S/C26H27N5O4S/c1-29-24(34)28-23(33)26(29)13-16-6-7-18(12-17(16)14-26)27-22(32)15-30-20-4-2-3-5-21(20)31(25(30)35)19-8-10-36-11-9-19/h2-7,12,19H,8-11,13-15H2,1H3,(H,27,32)(H,28,33,34)/t26-/m1/s1
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InChIKey
WMTYFICXHNNNJD-AREMUKBSSA-N
Physicochemical Property
logP
2.5288
Rotatable Bonds
4
Heavy Atom Count
36
Polar Areas
105.44
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44570499
ChEMBL ID
CHEMBL520778
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  3
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
2
IC50 = 220 nM
   TI
   LI
   LO
   TS
3
Ki = 13 nM
   TI
   LI
   LO
   TS