General Information of the Compound
Compound ID
CP0372067
Compound Name
(R)-N-(5-oxo-2-(pyridin-3-yl)-1,1',3',5-tetrahydrospiro[imidazole-4,2'-indene]-5'-yl)-2-(2-oxo-3-(pyridin-2-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetamide
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Structure
Formula
C30H23N7O3
Molecular Weight
529.56
Canonical SMILES
O=C(Cn1c2ccccc2n(-c2ccccn2)c1=O)Nc1ccc2C[C@]3(Cc2c1)N=C(NC3=O)c1cccnc1
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InChI
InChI=1S/C30H23N7O3/c38-26(18-36-23-7-1-2-8-24(23)37(29(36)40)25-9-3-4-13-32-25)33-22-11-10-19-15-30(16-21(19)14-22)28(39)34-27(35-30)20-6-5-12-31-17-20/h1-14,17H,15-16,18H2,(H,33,38)(H,34,35,39)/t30-/m1/s1
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InChIKey
NUCMLSBPZAAMPG-SSEXGKCCSA-N
Physicochemical Property
logP
2.6349
Rotatable Bonds
5
Heavy Atom Count
40
Polar Areas
123.27
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44570461
ChEMBL ID
CHEMBL472829
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 130 nM
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