General Information of the Compound
Compound ID
CP0366861
Compound Name
7-cyclohexyl-5,5-dimethyl-2-(3-piperazin-1-ylanilino)pyrrolo[2,3-d]pyrimidin-6-one
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Structure
Formula
C24H32N6O
Molecular Weight
420.561
Canonical SMILES
CC1(C)C(=O)N(C2CCCCC2)c2nc(Nc3cccc(c3)N3CCNCC3)ncc12
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InChI
InChI=1S/C24H32N6O/c1-24(2)20-16-26-23(28-21(20)30(22(24)31)18-8-4-3-5-9-18)27-17-7-6-10-19(15-17)29-13-11-25-12-14-29/h6-7,10,15-16,18,25H,3-5,8-9,11-14H2,1-2H3,(H,26,27,28)
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InChIKey
LOZGENZISGZHOI-UHFFFAOYSA-N
Physicochemical Property
logP
3.5867
Rotatable Bonds
4
Heavy Atom Count
31
Polar Areas
73.39
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 134130943
ChEMBL ID
CHEMBL3884535
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01667, MAP/microtubule affinity-regulating kinase 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 920 nM
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